Titlebook: Infantile Spasms; Diagnosis, Managemen James D. Frost,Richard A. Hrachovy Book 2003 Kluwer Academic Publishers 2003 development.diagnosis.d

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Epidemiology,ed are designed to extract meaningful relationships and correlations among multiple factors that may influence these basic parameters, and include a broad spectrum of experimental designs and biostatistical techniques. This chapter is more narrowly focused, and is primarily concerned with the demogr

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Clinical Manifestations,ny descriptions of the clinical features have been presented in the medical literature over the past 160 years, the details have varied considerably, and this has led to confusion regarding the precise characteristics of the disorder and the criteria for diagnosis (Lacy and Penry, 1976). The fundame

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Electroencephalography, Evoked Potentials, and Sleep,rictal EEG is nearly always abnormal, and the most characteristic pattern, hypsarrhythmia, is almost exclusively associated with this disorder. While other diagnostic procedures, including hematological and biochemical determinations, as well as imaging techniques (CT, MRI, PET and SPECT), are often

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Neurodiagnostic Imaging,btained at autopsy or during surgical procedures, in recent years greatly improved noninvasive imaging techniques have provided an additional source of information. The improved resolution of X-ray computed tomography (CT) and magnetic resonance imaging (MRI), in comparison to earlier techniques (pl

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Etiology and Pathology,ng central nervous system dysfunction are at increased risk for developing this disorder within the first year of life. But, this is not invariably true, and a significant number of cases occur in children who have apparently developed normally until the time of onset. In this chapter, we consider t

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Pathophysiology,ch have been etiologically associated with this disorder. As reviewed in Chapter 9, and summarized in Table 9.2, these include a variety of genetic disorders, many with specific central nervous system malformations and/or metabolic dysfunctions, neoplasms, damage induced by toxic agents, trauma, hyp

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