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Titlebook: Induced Pluripotent Stem Cells in Brain Diseases; Understanding the Me Vivi M. Heine,Stephanie Dooves,Judith Wagner Book 2012 The Author(s)

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發(fā)表于 2025-3-21 18:53:18 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書(shū)目名稱Induced Pluripotent Stem Cells in Brain Diseases
副標(biāo)題Understanding the Me
編輯Vivi M. Heine,Stephanie Dooves,Judith Wagner
視頻videohttp://file.papertrans.cn/464/463857/463857.mp4
概述Up-to-date review on the latest reprogramming techniques.Comprehensive overview of the epigenetic models and how these will help us to map cell identity, plasticity and fate.Current state and issues o
叢書(shū)名稱SpringerBriefs in Neuroscience
圖書(shū)封面Titlebook: Induced Pluripotent Stem Cells in Brain Diseases; Understanding the Me Vivi M. Heine,Stephanie Dooves,Judith Wagner Book 2012 The Author(s)
描述Brain diseases can have a large impact on patients and society, and treatment is often not available. A new approach in which somatic cells are reprogrammed into induced pluripotent cells (iPS cells) is a significant breakthrough for regenerative medicine. This promises patient-specific tissue for replacement therapies, as well as disease-specific cells for developmental modeling and drug treatment screening. However, this method faces issues of low reprogramming efficiency, and poorly defined criteria for determining the conversion of one cell type to another. Cells contain epigenetic “memories” of what they were that can affect reprogramming. This book discusses the various methods to reprogram cells, the control and determination of cell identity, the epigenetic models that have emerged and the application of iPS cell therapy for brain diseases, in particular Parkinson’s disease and Vanishing White Matter (VWM).?
出版日期Book 2012
關(guān)鍵詞epigenetics; induced pluripotent stem cell; neurology; regenerative medicine
版次1
doihttps://doi.org/10.1007/978-94-007-2816-5
isbn_softcover978-94-007-2815-8
isbn_ebook978-94-007-2816-5Series ISSN 2191-558X Series E-ISSN 2191-5598
issn_series 2191-558X
copyrightThe Author(s) 2012
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發(fā)表于 2025-3-21 21:43:34 | 只看該作者
Vivi M. Heine,Stephanie Dooves,Dwayne Holmes,Judith Wagnerhe software-engineering aspect has been dominant up to now on the part of computer science. The reason why is that in the meantime already good and refined systems exist on the market (CATIA,CADAM, CAEDS, CADIS, ICEM). But the integration capability of such systems has hardly been taken into conside
板凳
發(fā)表于 2025-3-22 01:31:30 | 只看該作者
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發(fā)表于 2025-3-22 06:24:14 | 只看該作者
Vivi M. Heine,Stephanie Dooves,Dwayne Holmes,Judith Wagner system consists of two parts..The first part is related to recognizing patterns. In this part, a method of constructing a discriminant-tree is proposed, where three newly defined measures called effectiveness, importance and applicability are introduced. The robot-arm-system is able to recognize th
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發(fā)表于 2025-3-22 10:26:54 | 只看該作者
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發(fā)表于 2025-3-22 14:26:23 | 只看該作者
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發(fā)表于 2025-3-22 18:15:16 | 只看該作者
Understanding Epigenetic Memory is the Key to Successful Reprogramming,noprecipitation (ChIP), and comprehensive high-throughput arrays for relative methylation (CHARM). Over the last few years, a body of work has emerged using such techniques to map the entire epigenetic landscape of ESCs, iPSCs, and terminally differentiated cells. In this way the underlying mechanis
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發(fā)表于 2025-3-22 23:41:56 | 只看該作者
Prospects for Cell Replacement Therapies for Neurodegenerative Diseases,hose affecting the brain. Different studies with animal models of neurological disease showed that cell grafts are able to improve clinical symptoms. The recent advances in the iPSC field encourage more neuroscientists to improve transplantation strategies for clinical purposes. Here we review precl
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發(fā)表于 2025-3-23 03:51:49 | 只看該作者
Conclusions,splantation. However, limits to the clinical use of iPSCs remain. It is also important to continue parallel studies into ESCs, given its longer history and consequently more advanced knowledge base. Both fields of research stand to benefit from each other, and so personalized SC therapies will devel
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發(fā)表于 2025-3-23 06:18:44 | 只看該作者
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