Titlebook: Indacaterol; The First Once-daily Alexandre Trifilieff Book 2014 Springer Basel 2014 Asthma.Beta-2-Agonists.Bronchitis.Bronchodilatator.Lun

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The Preclinical Pharmacology of Indacaterol,various in vitro systems, indacaterol is close to a full agonist at the human β.-adrenoceptor with nanomolar potency. In isolated superfused human and guinea pig trachea, indacaterol has a fast onset of and a long duration of action. In the conscious guinea pig, when given intratracheally as a dry p

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INHANCE: An Adaptive Confirmatory Study with Dose Selection at Interim,istical issues that must be considered when planning an adaptive design, for example, controlling the Type I error rate, prespecifying the adaptation criteria, and setting up well-organised procedures to maintain data confidentiality at interim analyses. The number of adaptations should be limited,

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of the truth. When evaluating the success of a cosmetic not medically indicated surgery our target should be to satisfy the subjective expectations of our customer. Such a subjective goal does not necessarily coincide with a visual acuity (VA) of 20/20 or decimally described VA of 1.0. Many social,