Titlebook: In silico Modeling and Experimental Validation for Improving Methanogenesis from CO2 via M. maripalu; Nishu Goyal Book 2016 Springer Scien

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Literature Review,ork. The information presented here gives a summarized overview and help us in exploring the metabolic processes and potential of hydrogenotrophic methanogens as well as deciphering the underlying mechanisms with the help of genome-scale engineering.

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Nishu GoyalProvides an original and comprehensive view on the metabolic process of M. maripaludis.Develops the first genome-scale metabolic model, iMM518, of M. maripaludis, to quantify the metabolic fluxes duri

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A Genome-Scale Metabolic Model of , S2 for CO, Capture and Conversion to Methane,Methane is a major energy source for heating and electricity. Its production by methanogenic bacteria is widely known in nature. . S2 is a fully sequenced hydrogenotrophic methanogen and an excellent laboratory strain with robust genetic tools. However, a quantitative systems biology model to complement these tools is absent in the literature.

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Flux Measurements and Maintenance Energy for CO, Utilization by ,,Genome-scale models are very useful for quantifying extracellular and intracellular fluxes, analyzing cultivation data, designing media and processes, and engineering microbial strains for enhanced production (Price et al. in Nat Rev Microbiol, 2:886–897, 2004 [.]; Pires et al. in Renew Sustain Energy Rev 16:3043–3053, 2012 [.]).

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Contributions and Future Recommendations,Rapid depletion of fossil fuel-based resources has caused energy and environmental concerns and encourages production of renewable chemicals and fuels from CO. consuming microorganisms.

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