Titlebook: In Vivo Inhalation Toxicity Screening Methods for Manufactured Nanomaterials; Toru Takebayashi,Robert Landsiedel,Masashi Gamo Book 2019 Sp

OATH

https://doi.org/10.1007/978-981-13-8433-2Short-Term Inhalation Study; STIS; Initial Hazard Data; Pulmonary Bioassay; Intratracheal Administration

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The Short-Term Inhalation Study (STIS) as a?Range Finder and Screening Tool in a?Tiered Grouping Strarly respiratory tract effects, the progression or reversibility of effects, pulmonary particle deposition, and potential test material translocation to extra-pulmonary tissues and the evolvement of systemic effects. This chapter provides details on the STIS study design focusing on aerosol characte

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Use of Short-Term Inhalation Study to Obtain Initial Hazard Data and Prepare for Subacute and Subchrice for acute toxicity testing, and a range-finding study for subacute and subchronic studies. The STIS can also be used to characterize the nanoparticle physicochemical properties and determine the type of exposure and particle monitoring methods in the inhalation chamber for subsequent subacute an

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Standardization of Intratracheal Instillation Study of Manufactured Nanomaterials However, many variables regarding sample preparation, experimental equipment, and technical procedures influence results from studies involving IT instillation, and a standard procedure has not yet been validated internationally. These drawbacks prevent accurate comparison of hazard information obt

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Development of Intratracheal Intrapulmonary Spraying (TIPS) Administration as a?Feasible Assay Metholusively sp., which gives MWCNT fibers their extraordinary properties. Production of MWCNTs is rapidly increasing because of their superiority over other materials. However, similarly to asbestos, MWCNTs are highly biopersistent in human tissues when inhaled and deposition in tissues causes sustaine