Titlebook: In Vitro Toxicity Testing Protocols; Sheila O’Hare,Chris K. Atterwill Book 1995 Springer Science+Business Media New York 1995

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verdict

Preparation and Use of Cultured Astrocytes for Assay of Gliotoxicitydures allow relatively rapid assessment of different chemicals or their metabolites over a range of concentrations, using cells derived from a restricted source. The use of multiwell plates for the cultural astrocytes means that multiple samples can be analyzed with a high degree of statistical accu

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北極熊

Cytotoxicity, DNA Fragmentation, and DNA Repair Synthesis in Primary Human Hepatocytesy in the extrapolation to humans of the results of toxicity studies carried out in laboratory animals or in in vitro systems employing as targets prokaryotes, lower eukaryotes, or mammalian cells. Growing evidence indicates that the most important cause of these species-related differences is the di

先驅(qū)

The FRAME Cytotoxicity Test (Kenacid Blue)-L1 cells (an established cell-line, ATCC CCL92.1), when maintained in culture continuously divide and multiply over time. The basis of this test is that a cytotoxic chemical (regardless of site or mechanism of action) will interfere with this process and, thus, result in a reduction of the growth r

FRET

Measurement of Cell Membrane Toxicity by Means of 2-Deoxy-D-Glucosed was first advanced to explain the toxic effects of heavy metals. The vital regulatory mechanisms inherent in the plasma membrane and its chemical composition make it susceptible to many toxic compounds (.). A toxic substance may cause structural alterations in the membrane by binding to or crossli

colony

Statins

SIRC Cytotoxicity Testll viability. A decrease in cell number, as measured by uptake of the dye Neutral Red, serves as an indicator of potential cytotoxicity. This test has been proposed as a potential replacement alternative for the Draize Eye Irritation test (.).