Titlebook: In Vitro Neurotoxicology; Principles and Chall Evelyn Tiffany-Castiglioni,Mannfred A. Hollinger Book 2004 Humana Press 2004

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In Vitro Neurotoxicology,at Ramón y Cajal’s theory on the developmental origin of nerve fibers was correct. Cajal had proposed in 1890, based on microscopic analysis of static histologic tissue sections, that the immature neuronal cell body sends out an axon that elongates freely, bearing a motile growth cone at its tip. Co

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Exposure-Dose-Response Paradigm as It Relates to Toxicogenomics,cy that masquerades as science, rather than representing a process well grounded in firm biological principles. Many toxicologists are uncomfortable when their work is linked to risk assessment or even when asked how their work will influence the risk assessment process. This chapter discusses the i

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Role of Apoptosis in Neurotoxicology,nervous system (CNS) from the embryonic stage through senescence, with different cells in each region of the nervous system having characteristic temporal patterns of programmed cell death. Several different stimuli trigger the apoptotic cascade, initiating diverse intracellular signaling pathways.

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Cell-Type Specific Responses of the Nervous System to Lead,t alters the activities of a particular cell type also induces secondary changes in the interactions between this cell and other cells. All types of cell in the nervous system are potential primary or secondary targets for damage by neurotoxic substances. The purpose of this chapter is to examine th

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