Titlebook: Impact of Survivin Acetylation on its Biological Function; David Dannheisig Book 2017 The Editor(s) (if applicable) and The Author(s), und

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Conscientious

BOON

思想流動

Material,Buffers, solutions and media which were used in the present work are listed below. If not denoted, buffers, solutions and media were prepared with Millipore H.O.

分離

LARK

Results,Survivin is part of the IAP family and fulfils a dual role in cells. Cytoplasmic survivin inhibits apoptosis and therefore mediates cell survival upon death stimuli. Nuclear survivin acts as a part of the chromosomal passenger complex (CPC) where it is involved in the regulation of chromosome segregation during mitosis.

做事過頭

Discussion,Survivin plays a crucial role in diverse cellular processes. The respective function depends on the subcellular localization as well as its dimerization state. Interestingly, only monomeric survivin can assemble in the CPC to ensure correct mitotic progress.

Forehead-Lift

978-3-658-18622-7The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Fachmedien Wies

哺乳動物

Impact of Survivin Acetylation on its Biological Function978-3-658-18623-4Series ISSN 2625-3577 Series E-ISSN 2625-3615

頭腦冷靜

Book 2017nucleocytoplasmic shuttling as well as dimerization behavior. Since survivin participates in two major hallmarks of oncogenesis, namely cell death inhibition and chromosomal segregation during the cell cycle, it reflects a valuable target in cancer therapy and research. The author establishes proxim