Titlebook: Immunotherapy of Cancer; Mary L. Disis Book 2006 Humana Press 2006 Antigen.T cell.cell.cell therapy.clinical trial.cytokine.cytokines.imag

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Discovery of Target Molecules for Cancer Immunotherapy by Genetic and Bioinformatic Approaches, them against target molecules expressed selectively on tumor cells. Different genetic approaches for discovery of such target candidates have been developed over the last 15 yr and are being pursued. The classical approaches apply expression cloning using either cancer-reactive T-lymphocytes or aut

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The Role of Immune Monitoring in Evaluating Cancer Immunotherapy,tended to induce. In this chapter, current cellular immune monitoring methods will be reviewed briefly in an effort to compare and contrast their utility. These methods include cytotoxicity and proliferation assays (radioactive and nonradioactive), cytokine assays (bulk and singlecell assays), and m

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Different Approaches to Dendritic Cell-Based Cancer Immunotherapy,We discuss requirements for tumor-associated antigens, antigen carriers, and selection of patients. Theoretical considerations are supported by specific experiments testing p53 vaccine in preclinical settings in vitro and in vivo.

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Anti-Idiotype Antibody Vaccines for the Immunotherapy of Cancer,nd functions of the external antigens and can be used as surrogate antigens for active specific immunotherapy. Several monoclonal anti-Id antibodies that mimic distinct human tumor-associated antigens have been developed and characterized by others and us. CeaVac (anti-Id 3H1) is an internal image a