Titlebook: Immunotherapy of Cancer; An Innovative Treatm Yoshiyuki Yamaguchi Book 2016 Springer Japan 2016 biomarkers.cancer vaccine.immune checkpoint

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WT1 Peptide Vaccine for the Treatment of Malignancies: Its Development, Recent Progress, and Future protein is highly immunogenic, which indicates that WT1 should be a promising target antigen for cancer immunotherapy. The identification of human WT1 cytotoxic T lymphocyte (CTL) epitopes and the demonstration using a mouse model that WT1 could serve in vivo as a target antigen for cancer immunoth

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Protein Vaccinen antigens are in general hardly processed by MHC class I pathway, combination with suitable antigen delivery systems and/or adjuvants is required for efficient CD8+ and CD4+ T-cell inductions for the clinical development of protein vaccine. Several protein vaccine types have been studied for their

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Dendritic Cell-Based Vaccine for Cancer, sipuleucel-T (Provenge.) and DCVax.-Brain, are approved in the USA and Switzerland, respectively. Furthermore, pivotal randomized phase III trials of several DC vaccines are ongoing in the USA and Europe. The promising data are also shown in retrospective as well as prospective clinical studies by

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αβ-T Cellsw large clinical trials. Even so, recent technical advances in such fields as genetic engineering may make it possible to cure various cancers using new candidates for αβ-T-cell therapy. It is expected that safe and effective αβ-T-cell therapy will be developed as a standard cancer therapy in the near future.

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Dendritic Cell-Based Vaccine for Cancers chapter, I introduce the results of representative clinical trials including sipuleucel-T and DCVax. and the process of Vaccell. development, consider the advantages of the DC vaccine for conventional vaccine, and discuss the problems and future prospects of the DC vaccine.

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