Titlebook: Immunobiology of Reproduction; Joan S. Hunt (Chairman) Conference proceedings 1994 Springer-Verlag New York, Inc. 1994 Immune System.Immun

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Cytokines and Pregnancy Recognitionystem (1). These signals ensure maintenance of the structural and functional integrity of the . (CL) that would otherwise regress at the end of the estrous or menstrual cycle. The CL produces progesterone, the hormone of pregnancy that is required to stimulate and maintain endometrial functions that

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Role of Locally Produced Growth Factors in Human Placental Growth and Invasion with Special Referencal as well as molecular interactions at this interface hold the secrets to two important biological riddles: (i) What protects the placenta, a fetally derived organ and thus genetically disparate from the mother, from destruction by the mother’s immune system? and (ii) What protects the uterus from

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Uterine Epithelial GM-CSF and Its Interlocutory Role During Early Pregnancy in the Mouse. Recent studies have shown that these cytokines are produced in a precisely orchestrated sequence during the reproductive cycle and are important components of the intercellular signaling language mediating in the actions of steroid hormones in reproductive tissues (1). Cytokines produced during th

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Novel Transforming Growth Factor Betas (TGFβ2) in Pregnancy and Cancer or fail. Certain cytokines have the potential to compromise the pregnancy and cause abortion:. (TNFα), . (IL-1), and . (IFNγ). This may involve activation of . (NK) lineage cells into . (LAK) cells that have the capacity to damage fetal trophoblast cells (2–7) that lie at the fetomaternal interface

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Tumor Necrosis Factor α: Potential Relationships with Cancers of the Female Reproductive Tractromoters of hematopoietic cell growth and differentiation in the bone marrow or as products of activated hematopoietic cells (6–8). Table 10.1 shows that genes encoding these factors are commonly, but not invariably, regulated by female sex steroid hormones. Pregnancy, where ovarian hormone levels r

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MHC Gene Expression in Placentas of Domestic Animalsese include the physical separation of fetal and maternal blood supplies and local nonspecific immunosuppressive effects of high concentrations of hormones in the uterus (1, 2). Additionally, there are components of these protective mechanisms that pertain directly to the mother’s immune system and

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MHC-Linked Genes and Their Role in Growth and Reproductioncognition, growth, and development in a variety of species (1–3). We have developed a hypothesis to relate these various functions, and it is shown in Figure 12.1. The MHC genes are primarily involved in the differentiation of self and nonself, and the regulation of their expression plays a major ro