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Titlebook: Immunization Against Alzheimer’s Disease and Other Neurodegenerative Disorders; Dennis J. Selkoe,Yves Christen Conference proceedings 2003

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發(fā)表于 2025-3-21 17:23:11 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書(shū)目名稱Immunization Against Alzheimer’s Disease and Other Neurodegenerative Disorders
編輯Dennis J. Selkoe,Yves Christen
視頻videohttp://file.papertrans.cn/463/462084/462084.mp4
概述Includes supplementary material:
叢書(shū)名稱Research and Perspectives in Alzheimer‘s Disease
圖書(shū)封面Titlebook: Immunization Against Alzheimer’s Disease and Other Neurodegenerative Disorders;  Dennis J. Selkoe,Yves Christen Conference proceedings 2003
描述.Promising effects in mice of immunization by ?-amyloid stimulated substantial research efforts and high hopes. In retrospect, this study appears simultaneously logical, consistent as it is with the amyloid theory central today in the field of Alzheimer‘s disease studies, and paradoxical, because it involved using the toxic substance itself for a treatment benefit. The research thus begun opens up multiple perspectives for experimentation and for treatment. Clinical trials began, but had to be stopped in January 2002 because of serious side effects. The editors‘ objective for this book is not to arouse false hopes for a therapeutic project that must still be proven, but to discuss the available?information and the questions it raises..
出版日期Conference proceedings 2003
關(guān)鍵詞Alzheimer‘s disease; Alzheimer′s disease; Prions; antibody; clinical trial; diagnosis; immunization; immuno
版次1
doihttps://doi.org/10.1007/978-3-642-59332-1
isbn_softcover978-3-642-63937-1
isbn_ebook978-3-642-59332-1Series ISSN 0945-6066 Series E-ISSN 2196-310X
issn_series 0945-6066
copyrightSpringer-Verlag Berlin Heidelberg 2003
The information of publication is updating

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Immunization Against Alzheimer’s Disease and Other Neurodegenerative Disorders978-3-642-59332-1Series ISSN 0945-6066 Series E-ISSN 2196-310X
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Research and Perspectives in Alzheimer‘s Diseasehttp://image.papertrans.cn/i/image/462084.jpg
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Immunologic and Tolerogenic Aspects of Amyloid Beta-Peptide: Implications for the Pathogenesis and xist in humans and, depending on genetic background, may expand in response to Aβ deposition in the brain and/or neurodegenerative cascades during aging. Further investigation of these endogenous immune responses to Aβ in humans may determine whether they contribute to, or protect against, AD and al
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,Improvements in Intranasal Amyloid-β (Aβ) Immunization in Mice,e was a dramatic, 12-fold increase in Aβ antibody titers in B6D2F1 mice treated two times a week for eight weeks compared to those of mice receiving i.n. Aβ without adjuvant. A non-toxic, mutant form of LT, designated LT(R192G), showed even better adjuvanticity; anti-Aβ antibody titers were 16-fold
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