Titlebook: Biologics in General Medicine; Wolf-Henning Boehncke,Heinfried H. Radeke Book 2007 Springer-Verlag Berlin Heidelberg 2007 Arthritis.Monito

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STYX

Infliximab: From the Idea to the Productle and membrane- bound TNF-α . Infliximab does not bind to TNF-β (lymphotoxin α ), a related cytokine that utilizes the same receptors as TNF-α. Thus infliximab was developed as a therapeutic agent for various inflammatory chronic diseases that are believed to be driven by the pro-inflammatory cytok

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macular-edema

The Production of Biopharmaceuticals chemical synthesis, biologics are made by biosynthesis in living cells. Biologics are generally much larger than traditional synthetic medicinal products and range from highly complex inactivated vaccines and plasma-derived factors to highly purified, well characterised recombinant therapeutic prot

埋葬

Treating Autoimmune Bullous Skin Disorders with Biologicsng distinct adhesionmolecules of the epidermis and dermoepidermal basement membrane zone leading to a loss of adhesive function of the target antigen(s) (Fig. 8.1). The appearance of blisters and erosions of the skin and/or mucous membranes is the leading clinical sign of autoimmune bullous skin dis

prediabetes

Biologics in Psoriasisune mediated inflammatory changes seen in psoriasis have been elucidated, leading to the development of biologics that specifically act on immunological mechanisms, which are thought to be pathogenic in psoriatic lesions. By acting on specific immunological actions in the large cascade that results

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Biologic Agents in Psoriatic Arthritisof the population, although estimates of its prevalence vary widely, and is generally considered an autoimmune disease with unknown antigenic determinants. There currently is no predictive marker indicating which psoriasis patients will develop arthritis (Mease 2004). PsA often is classified as a su