Titlebook: Hypoxia and Cancer; Biological Implicati Giovanni Melillo Book 2014 Springer Science+Business Media New York 2014 cancer.microenvironment.t

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Wie allein sind Alleinerziehende? of adaptive transcriptional changes mediated primarily by the hypoxia-inducible factor (HIF), and via stimulation of ion transport machinery maintaining normal intracellular pH. In addition, through these adaptive responses tumor cells acquire new features endowing them with selective advantage in

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,Rückblick auf die Zielsetzung,deed the presence of hypoxia in the primary tumor has been identified as a prognostic indicator of treatment outcome in a number of clinical settings. Hypoxic conditions can arise at the limits of oxygen diffusion from blood vessels (diffusion or chronic hypoxia) or as a consequence of vascular coll

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Wie aus Ideen Pr?sentationen werdens both a major challenge and a substantial opportunity in the treatment of cancer. These adaptations influence a wide range of cellular processes, including cell cycle, metabolism, oxygen delivery, proliferation, energy production, differentiation, replication, and sensitivity to growth and death si

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https://doi.org/10.1007/978-3-658-07452-4entral roles in tumour progression and resistance to cytotoxic chemotherapy and radiotherapy. While many molecular targets may offer synthetic lethal interactions with hypoxia, the development of prodrugs that are activated to generate cytotoxins by one-electron (1e) reduction in hypoxic cells repre

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