Titlebook: Hyperthermia; Haim I. Bicher,Duane F. Bruley Book 1982 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springe

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Results of a Phase I/II Clinical Trial of Fractionated Hyperthermia in Combination with Low Dose Iorial employing microwave hyperthermia in combination with low doses of ionizing radiation. In the protocol employed, each treated area received 8 hyperthermia treatments of 1.5 hour combined with 1600 rad over a total period of 5 weeks. Patients were heated with microwaves of 915 or 300 MHz employin

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Further Studies on the Nature of the Biphasic Radiation Survival Response of Chinese Hamster Cells ne (PBSA), the radiation survival response is biphasic with respect to oxygen concentration (1). At oxygen concentrations between 1.5 and 7.0 μM sensitization is constant, equivalent to an oxygen enhancement ratio of 1.9 compared with the full oxygen enhancement ratio of 3.1. This region of constant

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Oxygen Effects in Radiobiology,increased sensitivity of cells to damage fron ionizing radiation as the concentration of oxygen increases from 0 to about 20,000 ppm*. Above 20,000–50,000 ppm the radiation sensitivity remains about the same (see Ling et al, 1981 for one of the most accurate assessments). But oxygen affects many asp

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Oxygen, Hydrogen Donors and Radiation Response,Alpher, 1979; Elkind and Sinclair, 1965; Puch and Marcus, 1956; Hall, 1978; Groesch and Hopwood, 1979). The early studies of Gray et al., 1958, Fig. 1, indicate that as the oxygen concentration is lowered there is a corresponding decrease in the radiation response of cells. The relative radiosensiti

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Differential Response to Heat of Metastatic and Non-Metastatic Rat Mammary Tumors,es a selective and irreversible inhibition of metabolism in certain animal and human tumors correlated to cell killing (5–8). It remains uncertain, however, whether and under which conditions heat exerts a specific influence on tumor tissue since much of the information available is based on cells c

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Effects of Hyperthermia and Hyperglycemia on the Metastases Formation and on Survival of Rat Bearin3°C and 45–50°C. Most human tumors are not sensitive to 42–43°C temperature range (see Dickson and Shah, 1977), and temperatures greater than 42°C for prolonged periods can cause irreversible damage to normal surrounding tissues. Also, due to physiological limitations, disseminated disease cannot be

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Further Studies on the Nature of the Biphasic Radiation Survival Response of Chinese Hamster Cells ygen (3), there is as yet no other example for either bacterial (4) or mammalian cells (5, 6). The equation developed by Howard-Flanders and Alpher (7), which postulates that oxygen is in simple competition with target repair reactions, cannot be applied to this cell line. Furthermore, the shape of