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Titlebook: Humanized Mice for HIV Research; Larisa Y. Poluektova,J. Victor Garcia,Andrew M. Ta Book 2014 Springer Science+Business Media New York 201

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書目名稱Humanized Mice for HIV Research
編輯Larisa Y. Poluektova,J. Victor Garcia,Andrew M. Ta
視頻videohttp://file.papertrans.cn/430/429871/429871.mp4
概述Features mouse-to-human xenotransplantation/cross-reactivity of immune systems.Assesses the applicability of different mouse genetic backgrounds for humanization and human immune system function.Writt
圖書封面Titlebook: Humanized Mice for HIV Research; Larisa Y. Poluektova,J. Victor Garcia,Andrew M. Ta Book 2014 Springer Science+Business Media New York 201
描述.Over the last several years the field of humanized mice has matured and developed into an essential component of translational research for HIV/AIDS. Humanized mice serve both as vehicles for discovery and as highly sophisticated platforms for biomedical research. In addition, humanized mice have demonstrated outstanding potential for the investigation of critical aspects of the infection and pathogenesis of the hepatitis and herpes viruses, as well as highly relevant microbial infections such as tuberculosis and malaria. .Humanized Mice for HIV Research. provides a comprehensive presentation of the history, evolution, applications, and current state of the art of this unique animal model. An expansion of twelve review articles that were published in .Humanized Mice. by Springer in 2008 (Eds: Nomura T, Watanabe T, Habu S), this book expertly captures the outstanding progress that has been made in the development, improvement, implementation, and validation of humanized mouse models. The first two parts of this book cover the basics of human-to-mouse xenotransplantation biology, and provide critical information about human immune cell development and function based on individual mo
出版日期Book 2014
關(guān)鍵詞HIV; Immune system function; Mouse-to-human xenotransplantation; humanized mice
版次1
doihttps://doi.org/10.1007/978-1-4939-1655-9
isbn_softcover978-1-4939-4563-4
isbn_ebook978-1-4939-1655-9
copyrightSpringer Science+Business Media New York 2014
The information of publication is updating

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Thymic Education of Human T Cells and Regulatory T Cell Development in Humanized Miceis chapter, we summarize information on human T cell development, post-thymic interactions between T cells and APCs, as well as mechanisms maintaining tolerance that has been learned from these humanized mouse models.
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NK Cell Development in Human Immune System (HIS) Mice and Their Role in HIV Pathogenesisregulating HIV-induced pathology. In present chapter, we review some aspects of NK cell biology and the role of NK cells in HIV infection, and discuss the human NK cell engraftment in current HIS mouse models and possibilities to use HIS mice to study human NK cell during the course of HIV infection
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Phenotypical and Functional Properties of Antigen-Presenting Cells Derived from Humanized Mice for basic immunologic studies of human-innate immunity, but also provides a new and exciting tool for translational research in the area of infectious diseases such as HIV or sepsis and for the evaluation of vaccine candidates. However, a variety of questions still needs to be addressed to evaluate
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models. The first two parts of this book cover the basics of human-to-mouse xenotransplantation biology, and provide critical information about human immune cell development and function based on individual mo978-1-4939-4563-4978-1-4939-1655-9
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