| 書目名稱 | Human iPSC-derived Disease Models for Drug Discovery | | 編輯 | Markus H. Kuehn,Wei Zhu | | 視頻video | http://file.papertrans.cn/430/429604/429604.mp4 | | 概述 | Provides an exhaustive review of use of iPSC in pharmaceutics, iPSC-based modeling and materials science.Broadens your understanding of iPSC to model diseases of cardiovascular system, nervous system | | 叢書名稱 | Handbook of Experimental Pharmacology | | 圖書封面 |  | | 描述 | Since their development a decade ago, human induced pluripotent stem cells (iPSC) have revolutionized the study of human disease, given rise to regenerative medicine technologies, and provided exceptional opportunities for pharmacologic research. These cells provide an essentially unlimited supply of cell types that are difficult to obtain from patients, such as neurons or cardiomyocytes, or are difficult to maintain in primary cell culture. iPSC can be obtained from patients afflicted with a particular disease but, in combination with recently developed gene editing techniques, can also be modified to generate disease models. Moreover, the new techniques of 3 Dimensional printing and materials science facilitate the generation of organoids that can mirror organs under disease conditions. These properties make iPSC powerful tools to study how diseases develop and how they may be treated. In addition, iPSC can also be used to treat conditions in which the target cell population has beenlost and such regenerative approaches hold great promise for currently untreatable diseases, including cardiac failure or photoreceptor degenerations. | | 出版日期 | Book 2023 | | 關(guān)鍵詞 | iPSC; disease modeling; drug discovery; cardiovascular diseases; nervous system diseases; ophtalmology di | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-031-42349-9 | | isbn_softcover | 978-3-031-42351-2 | | isbn_ebook | 978-3-031-42349-9Series ISSN 0171-2004 Series E-ISSN 1865-0325 | | issn_series | 0171-2004 | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl |
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