| 書目名稱 | Human T-Cell Leukemia Virus | | 編輯 | Peter K. Vogt | | 視頻video | http://file.papertrans.cn/430/429543/429543.mp4 | | 叢書名稱 | Current Topics in Microbiology and Immunology | | 圖書封面 |  | | 描述 | characteristic features in common with the genome of other retroviruses: long terminal repeats (L TR), and coding regions for internal proteins (gag), for re- verse transcriptase (pol), and for glycosylated virion surface proteins (env) , ar- ranged in the sequence gag, pol, env from the 5‘ to the 3‘ end of the genome. However, the HTL V genome also contains some specific features not shared with all other retroviruses: the LTR regions are unusually long (745 base pairs, with 298 base pairs constituting the R region), but unlike the long L TRs of mouse mammary tumor viruses, they do not contain open reading frames. A stretch of noncoding sequences separates the gag and the pol genes. Most interestingly, the HTLV genome contains a region between the 3‘ end of the env gene and the L TR, called the pX region, that encompasses four open reading frames. Leukemic T cells freshly obtained from patients contain the HTL V provirus but usually do not express it. However, once established in culture, these cells produce viral proteins and release type C particles. Likewise, T cells infected and transformed by HTL V in vitro synthesize virus. Such producing cell lines have been widely used in | | 出版日期 | Book 1985 | | 關(guān)鍵詞 | cell; gene; leukemia; protein; proteins; retroviruses; tumor; virus | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-642-70113-9 | | isbn_softcover | 978-3-642-70115-3 | | isbn_ebook | 978-3-642-70113-9Series ISSN 0070-217X Series E-ISSN 2196-9965 | | issn_series | 0070-217X | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE |
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