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Titlebook: Human T Cell Clones; A New Approach to Im Marc Feldmann,Jonathan R. Lamb,James N. Woody Book 1985 The Humana Press Inc. 1985 AIDS.Antigen.a

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書目名稱Human T Cell Clones
副標(biāo)題A New Approach to Im
編輯Marc Feldmann,Jonathan R. Lamb,James N. Woody
視頻videohttp://file.papertrans.cn/430/429542/429542.mp4
叢書名稱Experimental Biology and Medicine
圖書封面Titlebook: Human T Cell Clones; A New Approach to Im Marc Feldmann,Jonathan R. Lamb,James N. Woody Book 1985 The Humana Press Inc. 1985 AIDS.Antigen.a
描述Most complex biological systems, such as enzyme pathways, are effec- tively controlled near the beginning of the process. There is increasing evidence that the same is true for the immune system, with the initial interactions between antigen, antigen-presenting cells, and T cells hav- ing a paramount influence on the ensuing events. Thus, analysis of the early stages of the immune responses has been a preoccupation of many immunologists. This has been considerably aided by the capac- ity to expand these early events, and ‘immortalize‘ them as clones of T cells, for detailed analysis. The discovery by Morgan, Ruscetti, and Gallo (Science 193, 1007, 1976) of T-cell growth factor (now termed interleukin-2 or IL-2) has had a major impact in immunology that is far from over. The greater ease of handling murine tissues experimentally, with the availability of more precisely defined reagents such as inbred strains, has meant that, to date, most of the work on long-term T-cell cultures has been per- formed in the mouse, as summarized by Fathman and Fitch (eds. , Iso- lation, Characterization and Utilization of T Lymphocyte Clones, Aca- demic Press, NY, 1982). However, the limitations of wo
出版日期Book 1985
關(guān)鍵詞AIDS; Antigen; autoimmune disease; interferon; transplantation
版次1
doihttps://doi.org/10.1007/978-1-4612-4998-6
isbn_softcover978-1-4612-9391-0
isbn_ebook978-1-4612-4998-6
copyrightThe Humana Press Inc. 1985
The information of publication is updating

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Experimental Biology and Medicinehttp://image.papertrans.cn/h/image/429542.jpg
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The Genes of the Murine T Cell Receptortigen, not alone, but in association the major histocompatibility complex (MHC, H-2 in the mouse). As a general rule cytotoxic T (Tc) cells recognize antigen in association with Class I MHC molecules and helper T (Th) cells do so with Class II structures (4,5).
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Molecular Studies of the Human T-Cell Antigen Receptorements in T-cells (4). The mouse and human cDNA probes most probably detect the β chain family of the T-cell antigen receptor since partial protein sequence analysis of a human T-cell β chain agrees with the translated nucleotide sequence of the human cDNA clone (7).
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SB-Specific CTL Clones Exhibit Functional Heterogeneity in their Susceptibility to Blocking by Anti-d that anti-T4 antibodies block cytolysis by interfering with formation of functional conjugates.. These and other findings have led to the hypothesis that the function of the T4 molecule is to bind to a non-polymorphic epitope on class II molecules and to thereby act as an ancillary structure that can facilitate T cell-target cell interactions..
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