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Titlebook: Human Retrotransposons in Health and Disease; Gael Cristofari Book 2017 Springer International Publishing AG 2017 Epigenetics.Genome.Germl

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發(fā)表于 2025-3-21 17:31:04 | 只看該作者 |倒序瀏覽 |閱讀模式
書目名稱Human Retrotransposons in Health and Disease
編輯Gael Cristofari
視頻videohttp://file.papertrans.cn/430/429425/429425.mp4
概述Authored by leading experts in the field.The first book to explore not only insertion-based effects and their related consequences on germline and somatic genome dynamics, but also the role and impact
圖書封面Titlebook: Human Retrotransposons in Health and Disease;  Gael Cristofari Book 2017 Springer International Publishing AG 2017 Epigenetics.Genome.Germl
描述This unique book explores the role of retrotransposons in?human?health and disease. The ability of retrotransposons to affect the structure of human genes is recognized since the late 80’s. However, the advances of deep-sequencing technologies have shed new light on the extent of retrotransposon-mediated genome variations. These progresses have also led to the discovery that retrotransposon activity is not restricted to the germline - resulting in inheritable genetic variations - but can also mobilize in somatic tissues, such as embryonic stem?cells, neuronal progenitor cells, or in many cancers. This book covers topics related to the effects of retrotransposon insertions, and their consequences on germline and somatic genome dynamics, but also discuss the role and impact of retrotransposons?sequences in a broader context, including a number of novel topics that emerged recently (long non-coding RNA, neuronal disorders, exaptation) with unexpected connections between retrotransposons,?stem cell maintenance, placentation, circadian cycles or aging..
出版日期Book 2017
關(guān)鍵詞Epigenetics; Genome; Germline; L1; lncRNA; Mutagenesis
版次1
doihttps://doi.org/10.1007/978-3-319-48344-3
isbn_softcover978-3-319-83917-2
isbn_ebook978-3-319-48344-3
copyrightSpringer International Publishing AG 2017
The information of publication is updating

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Retrotransposons and the Mammalian Germline,s the interplay between retrotransposons and their host cells in the mammalian germline, the genome defence systems that germ cells and pluripotent cells use to limit the mutagenic activity of retrotransposons, and the impact that retrotransposons are having on the biology of mammalian germ cells and pluripotent cells.
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發(fā)表于 2025-3-22 13:58:30 | 只看該作者
LINE-1 Retrotransposons as Neoplastic Biomarkers,nce of rare LINE-1 retrotransposition events. We are only beginning to understand the complex regulation of LINE-1 retrotransposons in cancer and how LINE-1 retrotransposon may help drive tumorigenesis in human neoplasias.
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發(fā)表于 2025-3-22 20:08:42 | 只看該作者
ne and somatic genome dynamics, but also the role and impactThis unique book explores the role of retrotransposons in?human?health and disease. The ability of retrotransposons to affect the structure of human genes is recognized since the late 80’s. However, the advances of deep-sequencing technolog
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發(fā)表于 2025-3-22 23:32:41 | 只看該作者
Retrotransposon-Derived Regulatory Regions and Transcripts in Stemness, presenting results on human and other mammalian pluripotent stem cells because of their importance in studying human health and evolution. Finally we also discuss the applications, implications, and questions that are raised from this newfound knowledge.
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發(fā)表于 2025-3-23 03:15:13 | 只看該作者
Gael CristofariAuthored by leading experts in the field.The first book to explore not only insertion-based effects and their related consequences on germline and somatic genome dynamics, but also the role and impact
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發(fā)表于 2025-3-23 06:36:22 | 只看該作者
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