Titlebook: Human Experimentation; Methodologic issues Ton J. Cleophas Book 1999 Springer Science+Business Media Dordrecht 1999 assessment.clinical re

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Carryover Effects in Clinical Research,ous treatment. This, so called, carryover effect may bias any clinical trial in which subjects are tested more than once. Crossover studies can be routinely checked for this bias. In other study designs, however, common sense and alertness for unusual patterns in the data are the only defenses again

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Between-Group Disparities in Drug Response,ter to treatment 1 and those who do so to treatment 2. The correlation between treatment response in such trials is negative. The current ANCOVA analysis for crossover studies does not allow for correlations being negative, and is, therefore, not adequate to test this kind of trials.

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978-0-7923-5827-5Springer Science+Business Media Dordrecht 1999

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Clinical Trials: New Endpoints,.. The Western community is currently increasingly involved in the problems of patients with chronic diseases. The wish to deal with such problems gives rise to new endpoints in medical research.