Titlebook: Human Apolipoprotein Mutants III; Diagnosis and Treatm Cesare R. Sirtori,Guido Franceschini,Bryan H. Brew Conference proceedings 1993 Sprin

異端邪說2

Structural and Functional Properties of Apo A-I Variants in Reconstituted HDLApo A-I determines the size of HDL subclasses, activates the reaction of lecithin cholesterol acyltransferase (LCAT) with HDL, and may participate in lipid transfers, and in the binding of HDL to cell surfaces. More than 20 natural mutants of apo A-I are known (von Eckardstein et al., 1990); most of

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Spontaneous Hypercholesterolemia in Pigse of the LDL receptor locus. Together, these mutations account for approximately 1% of the incidence of hypercholesterolemia in the human population. Since the estimated heritability coefficient for hypercholesterolemia is approximately 0.5, the quest is on to identify other gene loci that contribut

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The Apolipoprotein E Cys-142 Mutant: Role in Dominant Inheritance of Type III Hyperlipoproteinemia aipoprotein (apo) E that causes defective interaction of apoE with lipoprotein receptors and an accumulation of cholesterol-rich β-VLDL in the blood (Mahley and Rall, 1989). Most often, type III HLP is associated with homozygosity for an apoE mutant that has cysteine instead of arginine at residue 15

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Apolipoproteins as “Drugs”: Current Statusids and other chemicals, water soluble and in some cases presenting with a dominant positive or negative charge. In addition, some apolipoproteins can interact with cell receptors, either regulating cholesterol biosynthesis, or possibly cholesterol removal.

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Non-Mammalian Host Systems for the Expression of Mammalian Apolipoproteinsckhart et al. 1990; Yao et al. 1991), transgenic animals (Simonet et al. 1991), and bacteria (Vogel et al. 1985; Lalazar et al. 1988). These approaches have yielded considerable insight into the structure and function of several apolipoproteins but are rather limited for research or pharmaceutical p

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The Role of HDL Apolipoproteins in Mediating HDL Receptor Binding and Intracellular Cholesterol Efflheral tissues for delivery to the liver for excretion or reutilization (Glomset). While . evidence for this role of HDL is scant, many studies utilizing a variety of cultured cell types have demonstrated that HDL is able to promote the net efflux of cellular cholesterol (reviewed in Phillips et al).