Titlebook: Hormone Signaling; Vincent Goffin,Paul A. Kelly Book 2002 Springer Science+Business Media New York 2002 EGF receptor.G protein-coupled rec

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Gonadotropin and TSH Receptorsbunit and a specific β subunit. Chorionic gonadotropin (CG) is the fourth member of this family found only in human (hCG) and equine (eCG) species where it is synthesized by the placenta. It is also a heterodimeric hormone composed of the common α subunit and a specific β subunit highly homologous to the β LH subunit.

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Protein Phosphorylation and Protein-Protein Interactionse the molecular basis of signal triggering. Whatever the number or the type of proteins involved in signal transduction process within the cell, all known cascades involve one or, in most cases, two basic mechanisms: protein-protein interactions and protein phosphorylation.

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1566-0729 yogenesis and then for cell and organ systems to access and respond to an ever changing environmental milieu. Mediators of this constant exchange of information are growth factors, neurotransmmitters, peptide and protein hormones which bind to cell surface receptors and transduce their signals from

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Protein Phosphorylation and Protein-Protein Interactionstarget cells. The first step in hormone signaling involves the interaction between a ligand and its cognate receptor (membrane or nuclear), which in turn induces stoichiometric and conformational changes on the ligand-receptor complex. In the current state of the art, these modifications appear to b

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Control of Signaling by Tyrosine Phosphatases, proliferation and differentiation, the immune response, and cytoskeletal reorganization, by altering the levels of protein phosphorylation. The initial and crucial event for most signaling pathways inside the cell is protein tyrosine phosphorylation. Indeed, many transmembrane receptors for peptid

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The EGF Receptor Signaling System. Receptor binding by at least five genetically distinct ligands activates the intrinsic kinase resulting in EGFR tyrosyl-phosphorylating itself and numerous intermediary effector molecules, including closely-related c-erbB receptor family members. This action initiates a multitude of signaling path

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Insulin and Insulin-Like Growth Factor-1 Receptors and Signaling Pathways: Similarities and Different in serious medical consequences. Insulin is considered to be primarily a “metabolic” hormone with important effects on the normal homeostasis of glucose, fat and protein. If insulin production or insulin action at target tissues are impaired, diabetes and numerous concomitant conditions of insulin

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The JAK-STAT Pathwaye cytoplasmic tyrosine kinases that associate with cytokine receptor chains. These kinases are activated by cytokine binding, and then can phosphorylate the receptors on tyrosine residues. This in turn allows the recruitment of signal transducer and activator of transcription (STAT) proteins . their