書目名稱 | Histochemical and Immunohistochemical Techniques | 副標(biāo)題 | Applications to phar | 編輯 | Peter H. Bach,John Baker | 視頻video | http://file.papertrans.cn/428/427227/427227.mp4 | 圖書封面 |  | 描述 | Toxicological and pharmacological effects arise when chemicals interact with biophysiological functions in discrete cell types. There is a continuing need to screen novel compounds for their potential therapeutic effects, and once these have been "discovered" to understand their molecular actions, as the basis of using such compounds safely and for rational drug design. Pharmacology now uses all of the sophisticated molecular research techniques that are available for the development of safer and more efficacious drugs. Histochemistry has been usefully applied to developing new drugs (and assessing chemical safley) and is potentially cost effective. The need to test novel substances for their potential adverse effects has raised many questions. Toxicological pathology has moved away from the cataloging of lesions towards understanding the basis of the events that underly cell injury, especially for those secondary consequences of chemical injury that lead to malignancy and chronic disease. The focal nature of toxicologic lesions de- mands the use of microtechniques to provide data to help understand these questions. Histochemistry is under-utilized, but offers one of the key ap- pr | 出版日期 | Book 1991 | 關(guān)鍵詞 | cell; pathology; tissue; toxicology | 版次 | 1 | doi | https://doi.org/10.1007/978-94-011-3094-3 | isbn_softcover | 978-94-010-5370-9 | isbn_ebook | 978-94-011-3094-3 | copyright | Peter Bach and John Baker 1991 |
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