Titlebook: High-Throughput Screening Assays in Toxicology; Hao Zhu,Menghang Xia Book 2022Latest edition This is a U.S. government work and not under

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Acetylcholinesterase Inhibition Assays for High-Throughput Screeningry, attention, and learning. Inhibition of AChE activity can cause a variety of adverse health effects and toxicity. Identifying?AChE inhibitors quickly and efficiently?warrants?developing AChE inhibition assays in a quantitative, high-throughput screening (qHTS) platform. In this chapter, protocols

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GFP-LC3 High-Content Assay for Screening Autophagy Modulators, neurodegenerative diseases, and cardiovascular diseases. Therefore, it is useful to develop?an assay that can measure the functions of autophagy and also?be used to identify autophagy modulators by screening?a large number of compounds. This chapter describes a cell-based high content green fluore

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Zebrafish Behavioral Assays in Toxicologyssay platforms are available for multiple life stages (embryonic, juvenile, and adults) and are robust in detecting stressor-induced acute effects on neurodevelopment as well as long term deficits in sensory mechanisms, social behavior, learning, memory, and neurodegenerative diseases. Within this c

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High-Throughput Screening Assay Profiling for Large Chemical Databasesfrom government, industrial, and academic laboratories are screening millions of chemicals against a variety of biomolecular targets, producing an enormous amount of publicly available HTS assay data. These HTS assay data provide toxicologists important information on how chemicals interact with dif

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A Quantitative High-Throughput Screening Data Analysis Pipeline for Activity Profiling(qHTS) format, using triplicate 15-dose titrations to generate over 100 million data points to date. Counterscreens are also employed to minimize interferences from non–target-specific assay artifacts, such as compound autofluorescence and cytotoxicity. New data analysis approaches are needed to int

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