Titlebook: High-Risk Cutaneous Squamous Cell Carcinoma; A Practical Guide fo Chrysalyne D. Schmults Book 2016 Springer-Verlag Berlin Heidelberg 2016 M

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Genomics of SCC: Tumor Formation, Progression, and Future Therapeutic Implications for High-Risk Cutuppression, all of which contribute to squamous carcinogenesis. UV-carcinogenesis is understood mechanistically, causing a specific mutational ‘fingerprint’, but the extensive chromosomal aberrations causing gene copy number alterations and the massive burden of gene mutations make it very difficult

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Management of High-Risk Primary Tumors Including Nodal Staging as common as that from melanoma, renal carcinoma and oropharyngeal carcinoma. While most CSCCs are easily treatable and curable, this textbook focuses on the high-risk subset of CSCC which exhibits more aggressive behavior and has a significant risk of recurrence. While many treatment options exist

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Management of Nodal Metastasesses to draining regional lymph nodes. Most cSCC arise on the sun-exposed head and neck (HN) and subsequently the parotid and cervical nodes are the most frequent sites for the development of nodal metastases. Less frequently encountered are metastatic nodes involving the axilla or groin arising from

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Immune Dysfunction and Immunosuppression: Impacts on SCC Incidence, Prognosis, and Managementimmune dysfunction which serves as a nidus for many keratinocytic malignancies. Furthermore, patients with systemic immune dysfunction or dysregulation are subject to forming multiple SCCs and have a higher risk of developing biologically aggressive tumors. Proper balancing and targeting of immune f