Titlebook: Herpes Simplex Virus; Pathogenesis, Immuno Barry T. Rouse Book 1992 The Editor(s) (if applicable) and The Author(s), under exclusive licens

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Current Topics in Microbiology and Immunologyhttp://image.papertrans.cn/h/image/425950.jpg

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Regulation of Herpes Simplex Virus Type 1 Gene Expression,The . represent a large and diverse family of vertebrate pathogens and at least seven members of the group infect humans (R. 1990a). In this brief review, we shall discuss gene expression in herpes simplex virus (HSV) and point out those gene products which act as targets for the immune response.

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The Role of Antibody in Herpes Simplex Virus Infection in Humans,This chapter will attempt to critically analyze the role of antibody in the host’s response to herpes simplex virus (HSV) infection. Although the emphasis will be on the human, where relevant, selected animal data will be included.

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The Role of T Cell Immunity in Control of Herpes Simplex Virus, immunity. This participation can take the form of response modification, mediated by secreted physiologically active cytokines, or direct effector activity, as exemplified by cell-mediated cytolysis and the inhibition of viral replication by interferon-γ (IFN-γ).

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Macrophages and Other Nonspecific Defenses: Role in Modulating Resistance Against Herpes Simplex Vihages (MOs), natural killer (NK) cells, and polymorphonuclear granulocytes (PMNs). These cells, together with cytokines, play various roles at different stages in the pathogenesis of HSV infection (M. et al. 1985; M. 1979). Immunomodulation of nonspecific resistance is one useful approach to control

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