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Titlebook: Hepatitis C Virus: From Molecular Virology to Antiviral Therapy; Ralf Bartenschlager Book 2013 The Editor(s) (if applicable) and The Autho

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發(fā)表于 2025-3-21 18:21:57 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱Hepatitis C Virus: From Molecular Virology to Antiviral Therapy
編輯Ralf Bartenschlager
視頻videohttp://file.papertrans.cn/426/425714/425714.mp4
概述A comprehensive review.Written by leading experts.Richly illustrated.Includes supplementary material:
叢書名稱Current Topics in Microbiology and Immunology
圖書封面Titlebook: Hepatitis C Virus: From Molecular Virology to Antiviral Therapy;  Ralf Bartenschlager Book 2013 The Editor(s) (if applicable) and The Autho
描述.Hepatitis C virus (HCV), a major causative agent of chronic liver disease, is spread throughout the world and around 170 million people are persistently infected. In this volume, world-leading experts in the field of HCV research have compiled the most recent scientific advances to provide a comprehensive and very timely overview of the various facets of HCV. The book starts with a discussion of the possible origin of HCV and its spread among the human population. The focus of the subsequent chapters is on available cell culture and in vivo models before shifting to the molecular and cellular principles underlying the viral replication cycle. These chapters are complemented by insightful descriptions of the innate and adaptive immune responses to HCV as well as the virus-associated pathogenesis. Finally, the development of antiviral therapies, which is closely linked with progress in basic research, and the implementation of those therapies into present and future daily clinical practice are highlighted. .
出版日期Book 2013
關(guān)鍵詞Chronic liver disease; Disease pathogenesis; HCV entry; Immune response; RNA replication; RNA translation
版次1
doihttps://doi.org/10.1007/978-3-642-27340-7
isbn_softcover978-3-642-42936-1
isbn_ebook978-3-642-27340-7Series ISSN 0070-217X Series E-ISSN 2196-9965
issn_series 0070-217X
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE
The information of publication is updating

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Hepatitis C Virus Proteins: From Structure to Function,now actively being pursued as antiviral targets. The structural proteins, which form the viral particle, include the core protein and the envelope glycoproteins E1 and E2. The nonstructural proteins include the p7 viroporin, the NS2 protease, the NS3-4A complex harboring protease and NTPase/RNA heli
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Hepatitis C Virus RNA Translation,y the use of an internal ribosome entry site (IRES) element in the 5′-untranslated region (5′-UTR) of the viral RNA, the HCV RNA bypasses the need for nuclear processing events like capping and directly recruits the translation apparatus to the viral RNA to start translation of the viral proteins. I
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Adaptive Immune Responses in Hepatitis C Virus Infection,ed with an early neutralizing antibody response as well as vigorous and sustained HCV-specific CD4+ and CD8+ T cell responses. In persistent HCV infection, however, all three components of the antiviral adaptive immune response fail due to different viral evasion strategies. In this chapter, we will
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