Titlebook: Heat Shock Proteins in Neural Cells; Christiane Richter-Landsberg Book 2009 Springer-Verlag New York 2009 Alzheimer.Chaperone.Parkinson.pr

知識(shí)

Heat Shock Proteins and the Regulation of Apoptosis,eres of biomedicine. Within the last five years, research efforts have intensified, following the discovery of raised levels of heat shock protein (Hsp) expression in the brains of patients suffering from many neurodegenerative disorders, including Alzheimer’s, Parkinson’s and Huntington’s diseases

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Assembly of Protein Aggregates in Neurodegeneration, of proteins in inclusion bodies. To avoid this abnormal deposition of proteins the cells recruit molecular chaperones to suppress aggregation and the ubiquitin/proteasome pathway (UPP) to remove the aggregate-prone proteins. The UPP is the major nonlysosomal degradation pathway for intracellular pr

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,The Role of Heat Shock Proteins during Neurodegeneration in Alzheimer’s, Parkinson’s and HuntingtonMisfolded proteins and protein aggregation are controlled by molecular chaperones such as heat shock proteins (HSPs) that are constitutively and inducibly expressed in the nervous system. There is increasing evidence that HSPs could counteract common pathological mechanisms that take place during Al

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The Role of Hsps in Neuronal Differentiation and Development,erentiation. Overall, through their involvement in these various processes, expression of Hsps favours neuronal differentiation and survival and, as such, Hsps are emerging as important regulators of the delicate balance between cell death and survival/differentiation during development of the nervous system.

逗留

Small Heat Shock Proteins and the Cytoskeleton,logical disorders with glial pathology. In this chapter we focus on the sHSPs, their interaction with the cytoskeleton in neural cells during normal and stressful conditions, and their role in inclusion body formation where they might affect amyloid fibril formation and toxicity.

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Christiane Richter-Landsberg,Olaf Goldbaumk presents a number of key topics on novel hardware developments, thus providing the reader a good insight into the physical basis of ambient intelligence. It also indicates key research challenges that must be addressed in the future. .