Titlebook: Heart of the Matter; Key concepts in card Cesare Terracciano,Samuel Guymer Textbook 2019 Springer Nature Switzerland AG 2019 Angiogenesis.A

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Later Mechanisms of Cardiac Development,p. .. We will begin by exploring the establishment of the left-right axis, both in terms of ionic currents involved, the relevant signalling mediators and any mechanical interplay. We will then examine the development of the cardiac pacemaker, beginning from the electrical activity in the tubular he

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Myocardial Microstructure and Contractile Apparatus,ac function. Both the helical arrangement of cardiomyocytes and the orientation of sheetlets will be examined. The potential of a novel technique called diffusion tensor cardiovascular magnetic resonance (DT-CMR) will be discussed, in particular its ability to non-invasively assess the cardiac micro

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An Introduction to the Cardiac Action Potentials,. Several examples will be used to help appreciate the clinical implications of modifying this excitation system. We end with a brief introduction to the origin of the pacemaker potential and the contemporary theories surrounding its generation.

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Cardiac Excitation-Contraction Coupling,rchestrating myocardial contraction. The chapter explores the processes of excitation-contraction coupling (ECC) and calcium-induced calcium release (CICR) whilst appreciating the relevance of ECC in pathology and in engineering heart tissue.

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Conduction in Normal and Diseased Myocardium,avefront propagation and thus normal cardiac function are introduced. Finally, this chapter will explore how intercellular coupling can be altered in pathology, and the effects this has on the electrical function of the heart.

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The Scientific Rationale of Artificial Pacing, defibrillators (ICDs). This will involve a discussion of the three main categories of artificial pacemakers and a broad overview of the pacing modes available, in addition to a comparison of single vs. dual chamber pacing. Then, the indications of ICDs in both the primary and secondary prevention o

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