Titlebook: Heart of the Matter; Key concepts in card Cesare Terracciano,Samuel Guymer Textbook 2019 Springer Nature Switzerland AG 2019 Angiogenesis.A

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An Introduction to the Cardiac Action Potentials,. Several examples will be used to help appreciate the clinical implications of modifying this excitation system. We end with a brief introduction to the origin of the pacemaker potential and the contemporary theories surrounding its generation.

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Cardiac Excitation-Contraction Coupling,rchestrating myocardial contraction. The chapter explores the processes of excitation-contraction coupling (ECC) and calcium-induced calcium release (CICR) whilst appreciating the relevance of ECC in pathology and in engineering heart tissue.

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Developments in Heart Failure: Mechanical Unloading with LVADs, Exosomes, and MicroRNAs,e of left ventricular assist devices (LVADs) in advanced HF will then be explored, including a discussion of the underlying principles of mechanical unloading. We will then evaluate the emerging evidence of the role that exosomes and microRNAs may have in the diagnosis and treatment of cardiovascular diseases, including myocardial infarction.

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The Coagulation Cascade and its Therapeutic Modulation,the relevant signalling and cellular mediators of these dual processes. We will then discuss three key regulatory mechanisms, whilst simultaneously exploring the clinical relevance of both the aforementioned mechanisms and the aberrance of coagulation.

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