Titlebook: Handbook of the Extracellular Matrix; Biologically-Derived Fatima Raquel Azevedo Maia,J. Miguel Oliveira,Rui Living reference work 20230th

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Extracellular Matrix Isolation: Sources and Methods,be obtained by using chemical, physical, and enzymatic methods. The isolation of specific ECM components is feasible, while the achievement of fully preserved ECM complexity, including the preservation of the interactions between the different matrix components, is the main goal of the most recent E

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Extracellular Matrix Remodeling on Cancer Progression,rous proteins, which give the ECM its dynamic shape. In terms of tissue development and homeostasis, the ECM plays a major role. In addition, it serves as one of the major structural components of the tumor microenvironment. The ECM undergoes continuous remodeling processes due to the progression of

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Protein-Based Scaffolds for Musculoskeletal Tissue Repair and Regeneration,ion of blood cells (hematopoiesis), and maintaining postural stability. Damage or loss to the tissues of the musculoskeletal system impairs mobility and quality of life. Tissue engineering and regenerative medicine have significantly contributed to developing new therapeutic approaches for the treat

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Protein-Based Materials as Cancer In Vitro Models,nces malignancy and makes drug targeting a more difficult task. Protein-based materials as a substrate for cell culture hydrogels offer the advantage of having the presence of cell-responsive sequences as opposed to synthetic polymer-based hydrogels. This is important for cancer research to evaluate

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Proteins and Polypeptides as Biomaterials Inks for 3D Printing,compatibility with the ability to mimic the biochemistry of the cell’s extracellular matrix (ECM). The presence of multiple functional groups on the polymer chains of these naturally derived materials makes them suitable candidates for different crosslinking methods such as physical gelation, chemic

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Protein-Based Microfluidic Models for Biomedical Applications,lial tubes. By definition, microfluidic ECMs contain open and/or blind-ended channels with diameters on the order of 100 μm or smaller. They are designed to be immediately perfusable, and thus do not rely on biological tubulogenesis to form lumens. Methods to create the microfluidic networks can be