Titlebook: Handbook of Immunosenescence; Basic Understanding Tamas Fulop,Claudio Franceschi,Graham Pawelec Reference work 2019Latest edition Springer

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Lymphocyte Subtypes and Functions in Centenarians as Models for Successful Aging Immune system undergoes a progressive and profound remodeling of its functions with aging. This process is evidenced by a continuous change in the relative percentages, absolute number, and functionality of the subsets of lymphocytes that ultimately form the immune system..In this chapter, we descr

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Preclinical Animal Models for Developing Vaccines Against Influenza Infection for the Young and the ses. Vaccine candidates (e.g., based on live or inactivated virus, protein, DNA, or RNA) are usually identified and tested in preclinical studies using in vitro and in vivo models before they can be tested in humans. Designing appropriate vaccine formulations encompasses careful selection of the ant

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Measuring Immunological Age: From T Cell Repertoires to Populationslerate relative to chronological age. Nevertheless, there is a stage at which the immune system no longer properly responds to external or internal stressors, referred to as immunosenescence. If we understand the factors that affect the maintenance or decline of immune responses, we might learn to p

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Nonhuman Primate Models of Immunosenescence our health care system since advanced age is associated with a higher susceptibility to infectious diseases due to immune senescence. However, the mechanisms underlying age-associated dysregulated immunity are still incompletely understood. Advancement in our comprehension of mechanisms of immune s

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Using Insects as Models of ImmunosenescenceInsect models have been a key model for understanding the general process of aging (Hughes and Reynolds (Annu Rev Entomol 50:421–445, 2005); Lee et al. (Entomol Res 45:1–8, 2015)) although most studies to date have focused on understanding factors regulating life span. However, there is growing awar

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Study of T Cell Immunosenescence in Various Tissue Compartments human immunosenescence derive from the sampling of human blood, while the majority of T cells are noncirculating and reside in tissue sites. Discussed in this chapter is how human T cell development, differentiation, and maintenance are highly compartmentalized in distinct tissue sites: T cell deve

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The Role of the Bone Marrow for Adaptive Immunity in Old Ageof the total body lymphocyte pool. Only few studies have addressed this issue in lymphatic organs. The human BM represents an organ which has only recently been recognized as an important site for the regulation and maintenance of immunological memory. Intrinsic changes in adaptive immune cells as w