| 書目名稱 | Handbook of Chronic Myeloid Leukemia | | 編輯 | Timothy P Hughes,David M Ross,Junia V Melo | | 視頻video | http://file.papertrans.cn/421/420990/420990.mp4 | | 概述 | A small practical pocketbook that provides hematologists, oncologists, pathologists and other healthcare providers involved in the diagnosis and treatment of CML with a concise and up-to-date survey o | | 圖書封面 |  | | 描述 | This concise, clinically focused pocket handbook assembles and synthesizes the latest developments and trends in the diagnosis and treatment of CML and provides an authoritative and convenient summary of the latest progress in TKI trials, the molecular monitoring of CML responses, and the development of new therapies to overcome resistance and improve patient care. Chronic myeloid leukemia (CML) is a rare type of leukemia (1–2 per 100,000 people) but is the most common chronic myeloproliferative neoplasm. CML remains a key model for the improved understanding of the pathophysiology of a malignancy at a molecular level; CML was the first cancer to be associated with a recurring chromosome abnormality,?which generates the Philadelphia (Ph) chromosome and its associated fusion gene BCR-ABL1.?The clinical outcome for patients with CML has changed dramatically in the past 15 years and?this has been due to the development of tyrosine kinase inhibitors (TKIs), compounds that inhibit the activity of the oncogenic BCR-ABL1 protein.?A number of first-, second- and third-generation TKIs are now available for the?treatment of CML, although a number of treatment challenges remain, not least the | | 出版日期 | Book 2014 | | 關(guān)鍵詞 | BCR-ABL signaling; Hematology; Leukemia; Tyrosine kinase inhibitors; pharmacotherapy | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-319-08350-6 | | isbn_softcover | 978-3-319-08349-0 | | isbn_ebook | 978-3-319-08350-6 | | copyright | Springer International Publishing Switzerland 2014 |
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