Titlebook: HSF1 and Molecular Chaperones in Biology and Cancer; Marc Laurence Mendillo,David Pincus,Ruth Scherz-Sh Book 2020 Springer Nature Switzerl

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Chaperome Networks?– Redundancy and Implications for Cancer Treatmente where no redundant pathways can be deployed, and is a state of vulnerability, amenable for chaperome therapy. We conclude by proposing a change in how we discover and implement chaperome inhibitor strategies, and suggest an approach to chaperome therapy where the properties of chaperome networks,

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慢跑鞋

Lessons Learned from Proteasome Inhibitors, the Paradigm for Targeting Protein Homeostasis in Cancersurprisingly?complex. Here, we attempt to draw lessons from experience with proteasome inhibitors that may be relevant for other compounds targeting proteostasis in cancer, as well as extending the reach of proteasome inhibitors beyond blood cancers.

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Correction to: Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Per

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0065-2598 es currently under?clinical investigation to disarm the ability of the proteostasis network to support malignancy. This compendium is the first of its kind and aims to serve as a reference manual for active inv978-3-030-40206-8978-3-030-40204-4Series ISSN 0065-2598 Series E-ISSN 2214-8019

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The TRiC/CCT Chaperonin and Its Role in Uncontrolled Proliferationerted manner to regulate and transfer the genetic material to daughter cells. CCT (chaperonin containing TCP-1, also known as TRiC) is a molecular machine that forms a high molecular weight complex (1000?KDa). CCT is emerging as a key molecule during mitosis due to its essential role in the folding