Titlebook: HIV/AIDS: Immunochemistry, Reductionism and Vaccine Design; A Review of 20 Years Marc H V Van Regenmortel Book 2019 Springer Nature Switzer

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HIV/AIDS: Immunochemistry, Reductionism and Vaccine Design978-3-030-32459-9

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Reductionism and the Search for Structure: Function Relationships in Antibody Moleculesthe search should be for correlations rather than for causal relations. Methods used to find correlations between the atomic structure of antibody binding sites and their binding activity are mostly based on mutagenesis studies. Since the effect of any mutation depends on the molecular context, it i

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Graves’-disease

Basic Research in HIV Vaccinology Is Hampered by Reductionist Thinkingre discussed. These include (1) the failure to distinguish between the chemical nature of antigenicity and the biological nature of immunogenicity, (2) the belief that when an HIV-1 epitope is reconstructed by rational design to better fit a neutralizing monoclonal antibody (nMab), this will produce

lymphoma

Nature and Consequences of Biological Reductionism for the Immunological Study of Infectious Diseaserectionality of temporal changes that occur along the line. To validate the patterns detected by non-reductionist operations, reductionist procedures are needed. Integrated (non-reductionist and reductionist) methods can (i) distinguish data subsets that differ immunologically and statistically; (ii

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Limitations to the Structure-Based Design of HIV-1 Vaccine Immunogensd to several different epitopes. It is concluded that only trial and error, empirical investigations using numerous immunization protocols may eventually allow us to identify which mixtures of immunogens are likely to be the best candidates for an HIV-1 vaccine.

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Requirements for Empirical Immunogenicity Trials, Rather than Structure-Based Design, for Developingannot be expected to be present in identical form in the host to be vaccinated. It is possible to rationally design and optimize an epitope to fit one particular antibody molecule or to improve the paratope binding efficacy of a monoclonal antibody intended for passive immunotherapy. What is not pos

Instantaneous