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Nonhistone Proteins, Free Radical Defenses and Acceleration of Spherulation in ,odern . research has been on those areas directly related to growth and differentiation (22). Mitosis is synchronous following an interphase period of 8–10 h and mitotic synchrony implies metabolic synchrony (13). All events involved in the regulation of differentiation are therefore presumed to be

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Tubulin and Actin Gene Expression during the Cell Cyclend actin gene expression may, therefore, be related to specific cell cycle events. .., a ciliated protozoan, has been used extensively for cell cycle studies because a high degree of division synchrony may be induced in this system (18). Previous investigations of tubulin synthesis regulation, in di

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A Decrease in the Steady State Level of DNA Strand Breaks as a Factor in the Regulation of Lymphocytstem that is stimulated by ADP ribosylation, before blast transformation and DNA synthesis can occur. We now report that the production of DNA strand breaks in resting cells and their subsequent rejoining after stimulation are not single, unique, punctual events; there is rather a continuous product

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70 K Dalton Protein Synthesis and Heat Sensitivity of Chromatin Structure: Dependence on Cell Cyclehese changes at the molecular level is largely unclear. The use of supranormal temperatures has been found to induce striking changes on the nuclear level (12). In this respect it is of interest to study the modifications of chromatin by hyperthermia at successive stages of the cell cycle. One appro

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Involvement of Protein Kinases in Mitotic-Specific Eventsreakdown and chromosome condensation. Three specific proteins of the nuclear lamina, called lamins, become highly phosphorylated attendent to nuclear dissolution, and then are dephosphorylated as the nuclear membrane reforms (1). Concomitantly, histones become highly phosphorylated as chromosomes co

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