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Adult Growth Hormone Deficiency — the Clinical Picturef the GH–IGF-I axis, is, however, not associated with quickly recognised and conspicuous symptoms as often seen in failures of other hormonal systems – e.g. in insulin, cortisol, thyroid or sex steroid deficiency.

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Effects of GH on Bone Metabolism and Bone Masstudies, which demonstrate that GH exerts potent effects on bone remodeling, will be discussed in this chapter. Finally a hypothetical model for the mechanism of action of GH in the regulation of bone remodeling and bone mass will be presented.

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Amanpreet Kaur,Manpreet Kaur,Yamini Takhe “immune GH-IGF-I axis” acting in a paracrine/autocrine system between the immunocompetent cells has an important function, and at least in part may exert this function autonomously independent of the endocrine system.