Titlebook: Glycobiology of the Nervous System; Cara-Lynne Schengrund,Robert K. Yu Book 2023Latest edition The Editor(s) (if applicable) and The Autho

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Gewinner und Verlierer der Krise,e. Our group has pioneered research on the importance of gangliosides for growth factor receptor signaling and epigenetic regulation of NSC activity and differentiation. The primary localization of gangliosides is on cell-surface microdomains and the drastic dose and composition changes during neura

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https://doi.org/10.1007/978-3-658-23121-7ave a role in intercellular communication, serving as versatile biochemical signals (Kaltner et al, Biochem J 476(18):2623–2655, 2019) and in many cellular pathways. Anionic GSLs, the sialic acid containing gangliosides (GGs), are essential constituents of neuronal cell surfaces, whereas anionic sul

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https://doi.org/10.1007/978-3-8348-2227-7For the latter we have focused on three diseases that have seen especially intensive study in that regard: Parkinson’s, Alzheimer’s, and Huntington’s diseases. Parkinson’s disease (PD) has received the most intensive study with revelation of systemic deficiency of GM1 in brain and all peripheral tis

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Introduction to the Complexity of Cell Surface and Tissue Matrix Glycoconjugates,coproteins are the major constituents of mucus secretions of epithelia of various organs. Furthermore, the chapter draws attention to the incredible structural complexity and diversity of the glycan moieties of cell surface and extracellular glycoconjugates. Finally, the involvement of glycans as in

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Cells of the Central Nervous System: An Overview of Their Structure and Function,ns including physical support, maintenance of homeostasis, development and integration of synaptic activity. Oligodendrocytes form the myelin sheath which surrounds axons and enables rapid conduction of the nerve impulse. Microglia are the resident immune cells, providing immune surveillance and rem