Titlebook: Glucocorticoids; Nicolas J. Goulding,Rod J. Flower Book 2001 Springer Basel AG 2001 autoimmune disease.biology.drug.drug development.endoc

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The development of synthetic glucocorticoidsisone) and corticotropin in nine patients with rheumatoid arthritis. As stated by Munck and Guyre [.], the discovery of the anti-inflammatory effects of adrenal glucocorticoid hormones “dealt glu-cocorticoid physiology a blow from which it has yet to recover”. On the other hand, this discovery has f

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The glucocorticoid receptor: expression, function, and regulation of glucocorticoid responsiveness synthetic glucocorticoids to act on target tissues and elicit specific biological responses is dependent on the presence of the alpha isoform of the glucocorticoid receptor (GRα). GRα belongs to the superfamily of steroid/thyroid/retinoic acid receptor proteins that function as ligand-depend-ent tr

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Glucocorticoids and leukocyte adhesionies. The mode of action of GC is very complex and not yet fully elucidated, but a number of mechanisms have been described. Traditionally, selected anti-inflammatory actions of GC have been largely ascribed to the synthesis of a protein termed lipocortin 1 or annexin 1 (AnxAl), which inhibits phosph

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thyroid-hormone

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Systemic glucocorticoids in chronic arthritisf the most important advances in medical science this century. Philip Hench and his colleagues (who were awarded the Nobel Prize for discovering the anti-inflammatory properties of glucocorticoids) used them in rheumatoid arthritis (RA) with dramatic results [1]. The subsequent widespread use of glu

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Glucocorticoids in the control of inflammatory bowel disease, involving commonly the small bowel and or colon, and ulcerative colitis (UC), a condition confined to parts of or the entire large bowel (colon). About 5 to 10 per 100 000 inhabitants in Western countries are affected, with a peak incidence of onset of disease in their twenties causing a considera

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The development of synthetic glucocorticoidsonly partially solved by the newer compounds, which lack mineralocorticoid activity, but retain the metabolic effects of the natural hormones. In other words the most potent anti-inflammatory steroids also produce the most severe side-effects.