Titlebook: Glucocorticoid Signaling; From Molecules to Mi Jen-Chywan Wang,Charles Harris Book 2015 The Editor(s) (if applicable) and The Author(s), un

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Glucocorticoids and the Lungn. During lung development, expression of GR in the mesenchyme is required for normal terminal alveolar epithelial differentiation. Prenatal administration of exogenous glucocorticoids (GCs) to prevent neonatal respiratory distress syndrome, however, promotes alveolar maturation and accelerates surf

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Glucocorticoids and the Cardiovascular Systembiquitous in most cell types and conserved across species, highlighting its importance in development and homeostasis. Despite the fact that the glucocorticoid receptor is widely expressed, tissue-specific effects of glucocorticoids may have pronounced effects on whole organism phenotypes. Here we w

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Animal Models of Altered Glucocorticoid Signalingo the glucocorticoid receptor locus, but we will touch briefly on other relevant models including 11-β-HSD transgenics which alter tissue levels of ligand as well as mice with glucocorticoid excess. Of course, the number of mice with mutations in genes such as GR targets and transcriptional coregula

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https://doi.org/10.1007/978-1-4842-4961-1al observations. Thomas Addison described the syndrome of what came to be known as adrenal hormone insufficiency and Harvey Cushing the syndrome of glucocorticoid hormone excess. These dramatic and life-threatening conditions spawned 150 years of active research that has involved many disciplines; i

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Learn RPGs in GameMaker: Studiort a consequence of transcriptional regulation by the glucocorticoid receptor (GR). Activation of GR by glucocorticoids results in tissue-specific changes in gene expression levels with some genes being activated whereas others are repressed. This raises two questions: First, how does GR regulate di

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https://doi.org/10.1007/978-1-4842-1162-5he hormonal control of energy homeostasis in mammals. Whereas physiological levels of GCs are required for proper metabolic control, aberrant GC action has been linked to a variety of severe metabolic diseases, including type 2 diabetes and obesity. As a member of the nuclear receptor superfamily of

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