Titlebook: Germ Cell Development in C. elegans; Tim Schedl Book 2013 The Editor(s) (if applicable) and The Author(s), under exclusive license to Spri

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The Oocyte-to-Embryo Transition,onverted into a developmentally active, mitotically dividing embryo, arguably one of the most dramatic transitions in biology. This transition occurs very rapidly in ., with fertilization of a new oocyte occurring every 23 min and the first mitotic division occurring 45 min later. Molecular events r

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Epigenetic Control of Germline Development,are differentially regulated in the mitotic vs meiotic germ line, on X chromosomes vs autosomes and on paired chromosomes vs unpaired chromosomes. Small RNAs function in transposon silencing and developmental gene regulation. Histone modifications and small RNAs produced in the germ line can be inhe

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Using , to Explore the Evolution of the Germ Line, that are mediated by the rapid evolution of germ cell properties. Studies of . nematodes show how the otherwise conserved RNA-binding proteins (RBPs) that regulate germline development and differentiation can undergo surprisingly rapid functional evolution. This occurs even as the narrow biochemica

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Stem Cell Proliferation Versus Meiotic Fate Decision in ,,ell fate to the meiotic development fate. Whether a germ cell self-renews or enters meiotic prophase is largely determined by its proximity to the distal tip cell (DTC), which is the somatic niche cell that caps the distal end of the gonad. Germ cells close to the DTC have high levels of GLP-1 Notch

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