Titlebook: Genomic Applications in Pathology; George Jabboure Netto,Karen L. Kaul Book 2019Latest edition Springer International Publishing AG, part

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Current Massively Parallel Sequencing Technologies: Platforms and Reporting Considerationsquencing one small (several hundred bp) DNA region at a time, using a specific pair of complementary primers targeted to just that area of interest, the new sequencing platforms utilize a shotgun approach, randomly shearing the entire genome into over 300 million small fragments, sequencing each of

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Emerging Next-Generation Sequencing Technologies number variation, inversions, chromosomal rearrangements], epigenomic, and transcriptional. Long read lengths are required to enable efficient genomic assembly and accurate phasing, and the detection method must produce highly accurate base calls to minimize errors and reduce costly iterative seque

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Circulating Tumor Cells: Enrichment and Genomic Applicationsion of CTCs carries great potential as a tool in cancer patient management and prognostication. Numerous clinical trials on early and metastatic cancer are employing CTCs to evaluate the efficacy of systemic therapy. There is also an increasing interest in using CTCs for detailed molecular and cellu

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Genomic Pathology: Training for New Technologye testing, let alone genomic analysis. Pathologists, given their background in molecular diagnostics and experience directing clinical laboratories, must play a major role in translating genomic technology to patient care. This chapter reviews the significant progress that the pathology community ha

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Clinical Implementation of Next-Generation Sequencing (NGS) Assaysmolecular diagnostic laboratories for various indications. However, laboratory directors need to be prepared for the numerous challenges associated with the implementation of NGS technologies. These include the need to select an appropriate platform based on the purpose of the test, to recruit appro

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