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J. A. Meave,A. Rincón,M. A. Romero-Romerode los medicamentos y tecnologías sanitarias. Se empezó a utilizar a mediados de los a?os sesenta, y desde entonces se ha considerado como el tipo de análisis más apropiado para medir la eficiencia de los nuevos medicamentos y tecnologías sanitarias (1).

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Recent advances in fluorescence detection technology on CE, only 120 had been published. They stated ‘During the last decade the number of scientific papers published in this field has grown exponentially’ [1]. Expansion in publication has continued. Now, only five years after their review, the total number of the articles published in 1994 was nearl