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Titlebook: Genome Editing; The Next Step in Gen Toni Cathomen,Matthew Hirsch,Matthew Porteus Book 2016 The Editor(s) (if applicable) and The Author(s)

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發(fā)表于 2025-3-21 17:39:01 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱Genome Editing
副標(biāo)題The Next Step in Gen
編輯Toni Cathomen,Matthew Hirsch,Matthew Porteus
視頻videohttp://file.papertrans.cn/383/382831/382831.mp4
概述Will present most recent advances.in the basic understanding of mammalian host.DNA repair mechanisms.Reviews the most promising.approaches to stimulate high efficiency gene editing.Also focuses on gen
叢書名稱Advances in Experimental Medicine and Biology
圖書封面Titlebook: Genome Editing; The Next Step in Gen Toni Cathomen,Matthew Hirsch,Matthew Porteus Book 2016 The Editor(s) (if applicable) and The Author(s)
描述.This comprehensive volume explores human genetic engineering its pre-clinical and clinical applications, current developments, and as treatment for hereditary diseases. It presents and evaluates the most recent advances in the understanding of mammalian host DNA repair mechanisms, such as double-strand break induced gene targeting and mutagenesis, the development of zinc-finger nucleases, genome editing for neuromuscular diseases, phase integrases, triplex forming oligonucleotides and peptide nucleic acids, aptamer-guided gene targeting, AAV gene editing via DSB repair, engineered nucleases and trinucleotide repeat diseases, and creation of HIV-resistant cells. The expertly authored chapters contextualize current developments within the history of genome editing while also discussing the current and potential safety concerns of this rapidly growing field..Genome Editing: The Next Step in Gene Therapy., the latest volume in the .American Society of Gene and Cell Therapy?.series, deftly illuminates the potential of genetic engineering technology to eradicate today’s deadliest and most prolific diseases. It is ideal reading for clinicians and researchers in genetics and immunology.??
出版日期Book 2016
關(guān)鍵詞DNA Repair Mechanisms; gene therapy; Germline; Nuclease; Mutagenesis
版次1
doihttps://doi.org/10.1007/978-1-4939-3509-3
isbn_softcover978-1-4939-8061-1
isbn_ebook978-1-4939-3509-3Series ISSN 0065-2598 Series E-ISSN 2214-8019
issn_series 0065-2598
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines
The information of publication is updating

書目名稱Genome Editing影響因子(影響力)




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發(fā)表于 2025-3-21 21:40:53 | 只看該作者
Personal Journal, February 2013,SPR/Cas9— to introduce DSBs at specific sites in the genome for the purposes of modification is revolutionizing the biological and biomedical sciences. This chapter provides an overview of the research that led to these advances in gene editing and also summarizes DSB repair mechanisms in mammalian cells.
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發(fā)表于 2025-3-22 04:20:24 | 只看該作者
Christoph Lange,J?rg Langkau,Sebastian Baderhe parameters and approaches for nuclease-stimulated genome manipulation. Although much of the territory has been ceded in the last few years to the more easily designed TALENs and CRISPR/Cas nucleases, successful ZFNs are still in wide use in a number of applications, including current clinical trials.
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發(fā)表于 2025-3-22 06:38:59 | 只看該作者
Designing Digital Products for Kidste specifically via homologous recombination (HR) or targeted mutagenesis based mechanisms. In this chapter we will discuss the advances made in triplex technology involving triplex forming oligonucleotides (TFOs) and peptide nucleic acids (PNAs) for site specific genome editing.
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Gene Editing 20 Years Later,SPR/Cas9— to introduce DSBs at specific sites in the genome for the purposes of modification is revolutionizing the biological and biomedical sciences. This chapter provides an overview of the research that led to these advances in gene editing and also summarizes DSB repair mechanisms in mammalian cells.
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