| 書(shū)目名稱(chēng) | Genetic Modification of Hematopoietic Stem Cells | | 副標(biāo)題 | Methods and Protocol | | 編輯 | Christopher Baum | | 視頻video | http://file.papertrans.cn/383/382558/382558.mp4 | | 概述 | Provides an easily accessible reference volume for genetic modification of hematopoietic cells using various state-of-the-art vector systems.Comprehensive guide on functional, phenotypic and genotypic | | 叢書(shū)名稱(chēng) | Methods in Molecular Biology | | 圖書(shū)封面 |  | | 描述 | Gene Transfer into Hematopoietic Cells: From Basic Science to Clinical Application Christopher Baum 1. The Potential of Gene Transfer into Hematopoietic Vectors with the potential for stable transgene integration are Cells widely used in basic hematology and clinical trials of gene me- cine. In basic research, both gain-of-function and loss-of-fu- tion situations of individual genes can be created by gene transfer, leading to a wide range of applications in developmental biology, stem cell biology, immunology, leukemia research, and human genetics. With the first evidence of successful modification of murine hematopoietic cells using retroviral gene vectors (1, 2), researchers have also explored the therapeutic potential of this approach. To date, the emerging discipline of gene therapy is a highly diversified field that offers entirely novel approaches to treat a great variety of human diseases (3). All hematopoietic cell types are of major interest in this context, since the modification of the hematopoietic stem cell population may potentially give rise to a completely transgenic hematopoiesis with the potential to cure genetic disorders or fight severe chronic infections, and t | | 出版日期 | Book 2009 | | 關(guān)鍵詞 | Complex nucleic acids; DNA; Gene medicine; Gene transfer; Hematology; Hematopoiesis; Microarray; Mutagenesi | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-59745-409-4 | | isbn_softcover | 978-1-61737-866-9 | | isbn_ebook | 978-1-59745-409-4Series ISSN 1064-3745 Series E-ISSN 1940-6029 | | issn_series | 1064-3745 | | copyright | Humana Press 2009 |
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