Titlebook: Genetic Instability and Tumorigenesis; Michael B. Kastan Book 1997 The Editor(s) (if applicable) and The Author(s), under exclusive licens

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Antecedent

Commonwealth

https://doi.org/10.1007/978-3-662-26487-4cs, genetic epidemiology, tumor virology, chemical carcinogenesis, and others, have converged over the last few decades to provide many fundamental insights into the genetic basis of cancer. These studies have shown that the genesis of malignant tumors is dependent on the accumulation of a series of

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978-3-642-64434-4The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE

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Hemiplegia

Genomic Stability and Instability: A Working Paradigm,on. New concepts make us realize the magnitude of the challenge of duplicating and distributing an accurate copy of the genome each time a cell divides. For each of the 10. somatic cell divisions that occur in a human lifetime, each copy of the genome must contain an intact sequence of some 3 billio

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Genomic Instability and Its Role in Neoplasia,s to therapy. Genomic instability has been hypothesized to be a driving force behind multistep carcinogenesis (. 1976). A number of genetic changes are required for a normal cell to become tumorigenic (. 1959; . and . 1990). If genomic instability increases the rate at which these alterations occur,