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Titlebook: Genetic Epidemiology; Methods and Protocol Evangelos Evangelou Book 2018 Springer Science+Business Media, LLC, part of Springer Nature 2018

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發(fā)表于 2025-3-21 17:01:18 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書(shū)目名稱(chēng)Genetic Epidemiology
副標(biāo)題Methods and Protocol
編輯Evangelos Evangelou
視頻videohttp://file.papertrans.cn/383/382532/382532.mp4
概述Includes cutting-edge methods and protocols.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the experts
叢書(shū)名稱(chēng)Methods in Molecular Biology
圖書(shū)封面Titlebook: Genetic Epidemiology; Methods and Protocol Evangelos Evangelou Book 2018 Springer Science+Business Media, LLC, part of Springer Nature 2018
描述.This volume details fast-moving research while providing in-depth descriptions of methods and analytical approaches that are helping to understand the genome and how it is related to complex diseases. Chapters guide the reader through common and rare variation, gene-gene and gene-environment interactions and state-of-the-art approaches for the synthesis of genome-wide and gene expression data. Novel approaches for associations in the HLA region, family-based designs, Mendelian Randomization and Copy Number Variation are also presented. ?The volume concludes with the challenges researchers face while moving from identifying variants to their functional role and potential drug targets. Written in the highly successful .Methods in Molecular Biology. series format, chapters include introductions to their respective topics, a thorough presentation of methods and approaches and tips on troubleshooting and avoiding known pitfalls..
出版日期Book 2018
關(guān)鍵詞Genome variation; Multivariate; genetic epidemiology; polygenic traits; Mendelian Randomization
版次1
doihttps://doi.org/10.1007/978-1-4939-7868-7
isbn_softcover978-1-4939-9309-3
isbn_ebook978-1-4939-7868-7Series ISSN 1064-3745 Series E-ISSN 1940-6029
issn_series 1064-3745
copyrightSpringer Science+Business Media, LLC, part of Springer Nature 2018
The information of publication is updating

書(shū)目名稱(chēng)Genetic Epidemiology影響因子(影響力)




書(shū)目名稱(chēng)Genetic Epidemiology影響因子(影響力)學(xué)科排名




書(shū)目名稱(chēng)Genetic Epidemiology網(wǎng)絡(luò)公開(kāi)度




書(shū)目名稱(chēng)Genetic Epidemiology網(wǎng)絡(luò)公開(kāi)度學(xué)科排名




書(shū)目名稱(chēng)Genetic Epidemiology被引頻次




書(shū)目名稱(chēng)Genetic Epidemiology被引頻次學(xué)科排名




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沙發(fā)
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板凳
發(fā)表于 2025-3-22 02:29:17 | 只看該作者
https://doi.org/10.1007/978-1-4939-7868-7Genome variation; Multivariate; genetic epidemiology; polygenic traits; Mendelian Randomization
地板
發(fā)表于 2025-3-22 04:57:09 | 只看該作者
Medienkonzentration und Medienkonzerneion by determining both exposures and outcomes at one time point. Cohort studies identify the study groups based on the exposure and, then, the researchers follow up study participants to measure outcomes. Case-control studies identify the study groups based on the outcome, and the researchers retro
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發(fā)表于 2025-3-22 12:25:42 | 只看該作者
Nationale und internationale Filmproduktiont emerged in the mid-1980s bringing together approaches and techniques developed in mathematical and quantitative genetics, medical and population genetics, statistics and epidemiology. The purpose of this chapter is to familiarize the reader with key concepts in genetic epidemiology as applied at p
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發(fā)表于 2025-3-22 13:36:51 | 只看該作者
https://doi.org/10.1007/978-3-642-86069-0a and thresholds have been established for data QC at the sample and variant level. Sample QC is aimed at the identification and removal (when appropriate) of individuals with (1) low call rate, (2) discrepant sex or other identity-related information, (3) excess genome-wide heterozygosity and homoz
7#
發(fā)表于 2025-3-22 18:01:31 | 只看該作者
Michael Fischer M.Sc., Dipl.-Krim.nome-wide association studies (GWAS). In this chapter, we review the key concepts that underlie the GWAS approach. We will describe the “common disease, common variant” theory, and will review how we finally afforded to capture the common variance in genome to make GWAS possible. Finally, we will go
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發(fā)表于 2025-3-23 00:12:51 | 只看該作者
Problemstellung und Untersuchungskonzeption, rarer frequency spectrum of the genome has not yet been comprehensively explored. Technological developments increasingly lift restrictions to access rare genetic variation. Dense reference panels enable improved genotype imputation for rarer variants in studies using DNA microarrays. Moreover, the
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發(fā)表于 2025-3-23 01:31:10 | 只看該作者
https://doi.org/10.1007/978-3-642-92786-7dies, and is extensively used in the genomic analyses of complex traits. Estimates from different studies are combined and the results effectively provide the power of a much larger study. Meta-analysis also has the potential of discovering heterogeneity in the effects among the different studies. T
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發(fā)表于 2025-3-23 06:01:02 | 只看該作者
https://doi.org/10.1007/978-3-211-76520-3e been made in identifying genetic variants associated with complex traits through more dense panels of genetic variants and larger sample sizes, genome-wide interaction analyses are still limited in power to detect interactions with small effect sizes, rare frequencies, and higher order interaction
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