Titlebook: Genetic Consequences of Nucleotide Pool Imbalance; Frederick J. Serres Book 1985 Plenum Press, New York 1985 DNA.Nucleotide.enzyme.gene.ge

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書目名稱Genetic Consequences of Nucleotide Pool Imbalance影響因子(影響力)




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Thymineless Mutagenesis in Bacteriaest that removal of uracil from DNA plays a role in the generation of frameshift mutations by thymine deprivation. A model that involves nucleotide misincorporation into DNA and induction of error-prone repair functions in response to thymine starvation is proposed to account for these findings.

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Thymineless Death and Genetic Events in Mammalian Cellsortions of the genome and in some specific manners in contrast to those induced by X-ray, which occurred rather randomly. Cycloheximide blocked thymineless death and accumulation of the double stranded DNA fragments in parallel. The double strand breaks induced by thymidine starvation were not repai

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Induction of Mitochondrial Mutations in Human Cells by Methotrexatedium. This mitochondrial specific mutagenesis can also be achieved using the thymidylate synthetase inhibitor, 5-fluorodeoxyuridine further implicating thymidylate pools as the mediator of this effect. During the course of exposure to 10. M MTX the thymidine kinase deficient HeLa BU25 cell line exhi

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Digitalisierung in Unternehmen,he fidelity of DNA synthesis . as a function of the relative concentration of nucleotides. We will also consider recent studies suggesting that DNA-damaging agents alter nucleotide metabolism in cells.

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