| 書(shū)目名稱 | Generalized Non-Convulsive Epilepsy: Focus on GABA-B Receptors | | 編輯 | C. Marescaux,M. Vergnes,R. Bernasconi | | 視頻video | http://file.papertrans.cn/383/382239/382239.mp4 | | 叢書(shū)名稱 | Journal of Neural Transmission. Supplementa | | 圖書(shū)封面 |  | | 描述 | Generalized non convulsive epilepsy (GNCE), also called absence or petit mal epilepsy, is a disease appearing during childhood. EEG, clinical, pharmacological and genetic characteristics differ from those of convulsive or focal epilepsies. No underlying structural or biochemical abnormality has been identified for generalized absence seizures and the etiology of this disorder is unknown. It is unlikely that the precise pathophysiology of GNCE can be resolved in studies that focus on humans. Therefore a number of animal models reproducing the human disease have been developed. The aim of this supplementum is to characterize such models in rodents. First, recent models are extensively described. These include the genetic model of spontaneous GNCE in Strasbourg‘s Wistar rats and in tottering mice as well as bilateral spike and wave discharges induced by GHB, PTZ or GABA mimetics. Second, this supplementum will also provide very recent information on putative mechanisms underlying generalized absence seizures. Third, various experimental approaches aimed at investigating the neural substrate of this particular kind of epilepsy are described with various electrophysiological, pharmacolo | | 出版日期 | Conference proceedings 1992 | | 關(guān)鍵詞 | Epilepsie; GABA; electroencephalography (EEG); metabolism; pathophysiology; physiology; research | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-7091-9206-1 | | isbn_softcover | 978-3-211-82340-8 | | isbn_ebook | 978-3-7091-9206-1Series ISSN 0303-6995 | | issn_series | 0303-6995 | | copyright | Springer-Verlag Wien 1992 |
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